![]() Besides, new actors in the pathogenesis of liver and cardiovascular damage in NAFLD are emerging, such as genetic background, fructose consumption, hyperuricemia, and vitamin D deficiency. Notably, the same factors have been confirmed as predictors of cardiovascular events among patients with NAFLD. In this complex landscape, a number of metabolic factors like obesity, insulin resistance (IR) and diabetes have been identified as involved in the pathogenesis and progression of liver fibrosis. The pathogenesis of NAFLD is multifaceted and incompletely understood. A considerable proportion of patients with NAFLD is at risk of progression to cirrhosis, and development of cancer and cardiovascular events. In a short time, the current epidemic of overweight and obesity may lead to an increase in prevalence of non-alcoholic fatty liver disease (NAFLD), a major cause of chronic liver disease worldwide. 2010C4JJWB_001).Ĭompeting interests: The authors have declared that no competing interests exist. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are creditedĭata Availability: All relevant data are within the paper and its Supporting Information files.įunding: This study was funded by grants from the PRIN 2010-2011 (Prot. ![]() Received: AugAccepted: OctoPublished: December 16, 2015Ĭopyright: © 2015 Petta et al. Sookoian, Institute of Medical Research A Lanari-IDIM, University of Buenos Aires-National Council of Scientific and Technological Research (CONICET), ARGENTINA (2015) Obstructive Sleep Apnea Is Associated with Liver Damage and Atherosclerosis in Patients with Non-Alcoholic Fatty Liver Disease. You may report side effects to FDA at 1-80.Citation: Petta S, Marrone O, Torres D, Buttacavoli M, Cammà C, Di Marco V, et al. Call your doctor for medical advice about side effects. This is not a complete list of side effects and others may occur. Liver problems-loss of appetite, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).Ĭommon side effects of Tylenol PM may include: Stop using the medicine and call your doctor at once if you have: The medicine may cause serious side effects. If you have this type of reaction, you should never again take any medicine that contains acetaminophen. Stop taking this medicine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling. This could occur even if you have taken acetaminophen in the past and had no reaction. In rare cases, acetaminophen may cause a severe skin reaction that can be fatal. Get emergency medical help if you have signs of an allergic reaction: hives difficult breathing swelling of your face, lips, tongue, or throat. Store at room temperature away from moisture and heat. If you need surgery or medical tests, tell the doctor ahead of time if you have taken this medicine within the past few days. Also call your doctor if your symptoms get worse, or if you have any redness or swelling. Death can occur from the misuse of antihistamines in very young children.ĭo not use this medicine for longer than 2 weeks to treat sleep problems, or longer than 7 days to treat cold or allergy symptoms.Ĭall your doctor if you still have a fever after 3 days, or you still have pain after 10 days (or 5 days if you are 12-17 years old). Do not use the medicine to make a child sleepy. Tylenol PM is not for use in anyone younger than 12 years old. ![]() Taking too much diphenhydramine can lead to serious heart problems, seizures, coma, or death. ![]() An overdose of acetaminophen can damage your liver or cause death. ![]() Tylenol PM is only for short-term use until your symptoms clear up.ĭo not take more of this medicine than is recommended. Use exactly as directed on the label, or as prescribed by your doctor. ![]()
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